Resilience was subcontracted to help execute an evaluation of the research funding program “Meer Kennis met Minder Dierproeven” (More Knowledge with Fewer Animals), that aims at stimulating the development in “3R alternatives” of animal testing: Replacement, Reduction and Refinement”. The study was contracted by the Netherlands Organisation for Health Research and Development and in collaboration with Technopolis Group. The methodology combined a portfolio and social network analysis, interviews, and an analysis of project and internal documentation. In a second project executed together with Technopolis Group “Analyse business case alternatieven voor dierproeven” (Analysis business case alternatives for animal experiments), we developed a policy advice with possibilities for alternatives to animal experiments for the Ministry of Economic Affairs. Three scenarios earlier developed by experts were analysed and further developed to get more insight into their feasibility. The analysis was based on the results of a literature study, an extensive survey, expert interviews and expert workshops.